For licensed healthcare professionals. The protocol figures below are drawn from published labeling and peer-reviewed literature for educational reference. They are not a prescription, not a recommendation, and not a substitute for the dispensing pharmacy's labeling or your own clinical judgment.

Cognitive & Mood

Methylene Blue

Not WADA-listed

Thiazine dye with mitochondrial-electron-shuttle activity. Approved for methemoglobinemia; off-label low-dose oral use for cognition.

At a glance

Common vial size: Not vial-based
Reference dose: 15 mg
Frequency: Once daily, oral

Reference titration protocol

Oral 15–30 mg/day; low-dose hormetic window. Avoid serotonergics, G6PD CI.

Reference titration ladder for Methylene Blue
Step	Dose	Duration	Administrations / week
1	15 mg	4 weeks	7×

Clinical notes

Serotonin-syndrome risk with SSRIs/MAOIs
Stains urine and mucosa blue

Available formulations

Presentations carried across the VitaRelay pharmacy network, including 503A compounded, 503B outsourcing facility, and research & development sourcing. Pricing and state-level availability are shown to verified accounts only.

10 ml · Injectable503B
Capsule/TabletRUO
Capsule/Tablet503A

References

Tucker et al., CNS Drugs 2018

Often used with

Compounds commonly discussed alongside Methylene Blue in published protocols and prescriber requests. Listed for reference only — not a clinical recommendation, and not a suggestion to co-administer.

Pricing and ordering are for verified accounts

VitaRelay serves licensed practices, prescribers, and pharmacies. Catalog pricing, availability by state, and ordering are available after your account is verified.

Educational information for licensed healthcare professionals

The material on this page is general educational information intended for licensed healthcare professionals and their clinical staff. It is not medical advice, is not a substitute for professional judgment, and does not establish a provider-patient relationship. Nothing here should be read as a recommendation for, or endorsement of, any specific therapy, product, or course of treatment. Compounded preparations must be handled in accordance with applicable federal and state law, the dispensing pharmacy's labeling, and your own institutional policies. All clinical decisions — including product selection, preparation, dosing, and administration — remain the sole responsibility of the treating licensed practitioner.

VitaRelay is a technology and logistics network. We are not a pharmacy, prescriber, or distributor. See our Terms of Service and service availability for details.