For licensed healthcare professionals. The protocol figures below are drawn from published labeling and peer-reviewed literature for educational reference. They are not a prescription, not a recommendation, and not a substitute for the dispensing pharmacy's labeling or your own clinical judgment.

GLP-1 / Incretin

Retatrutide

aka LY3437943

Not WADA-listed

Triple GLP-1/GIP/glucagon receptor agonist. Phase III; ~24% weight loss reported in Phase II at 48 weeks.

At a glance

Common vial size: 10 mg
Reference dose: 12 mg
Frequency: Once weekly

Reference titration protocol

2 → 12 mg titration, step every 4 weeks, once weekly. Investigational.

Reference titration ladder for Retatrutide
Step	Dose	Duration	Administrations / week
1	2 mg	4 weeks	1×
2	4 mg	4 weeks	1×
3	6 mg	4 weeks	1×
4	8 mg	4 weeks	1×
5	10 mg	4 weeks	1×
6	12 mg	4 weeks	1×

Reconstitution example

A 10 mg vial reconstituted with 2 mL of bacteriostatic water yields 5 mg/mL. Confirm the diluent and volume against the labeling that ships with the vial.

Open this configuration in the calculator

Clinical notes

Not FDA approved — investigational only
Phase III TRIUMPH program ongoing

Available formulations

Presentations carried across the VitaRelay pharmacy network, including 503A compounded, 503B outsourcing facility, and research & development sourcing. Pricing and state-level availability are shown to verified accounts only.

Injectable503A

References

Phase II trial (NEJM)

Often used with

Compounds commonly discussed alongside Retatrutide in published protocols and prescriber requests. Listed for reference only — not a clinical recommendation, and not a suggestion to co-administer.

Pricing and ordering are for verified accounts

VitaRelay serves licensed practices, prescribers, and pharmacies. Catalog pricing, availability by state, and ordering are available after your account is verified.

Also in GLP-1 / Incretin

Semaglutide

GLP-1 receptor agonist for type 2 diabetes and chronic weight management. Standard 16-week titration to target dose.

Tirzepatide

Dual GIP/GLP-1 receptor agonist. 5-dose escalation (2.5 → 15 mg) over 20+ weeks. Up to ~22% weight loss in SURMOUNT-1.

Survodutide

Dual GLP-1/glucagon agonist. Phase III for obesity and MASH. ~52% liver-fat reduction reported in Phase II.

CagriSema

Fixed-dose combination of amylin analog cagrilintide with semaglutide. Phase III REDEFINE program.

Educational information for licensed healthcare professionals

The material on this page is general educational information intended for licensed healthcare professionals and their clinical staff. It is not medical advice, is not a substitute for professional judgment, and does not establish a provider-patient relationship. Nothing here should be read as a recommendation for, or endorsement of, any specific therapy, product, or course of treatment. Compounded preparations must be handled in accordance with applicable federal and state law, the dispensing pharmacy's labeling, and your own institutional policies. All clinical decisions — including product selection, preparation, dosing, and administration — remain the sole responsibility of the treating licensed practitioner.

VitaRelay is a technology and logistics network. We are not a pharmacy, prescriber, or distributor. See our Terms of Service and service availability for details.